Publications - Ju Chen Lab

Below is a list of select publications.
Find a current list of publications from Ju Chen on NIH/Pubmed

before [1998]

Sahota A, Chen J, Asako K, Takeuchi H, Stambrook PH, Tischfield JA Identification of a common nonsense mutation in Japanese patients with Type I adenine phosphoribosyltransferase deficiency. Nucleic Acids Res 15:5915-5916, 1990

Gathof B, Sahota A, Gresser U, Chen J, Stambrook PS, Tischfield JA, Zollner N. Identification of a splice mutation in the adenine phosphoribosyltransferase locus in a German family. Klin Wochen 69:1152-1155, 1990

Gathof B, Sahota A, Gresser U, Chen J, Stambrook PS, Tischfield JA, Zollner N. A splice mutation at the adenine phosphoribosyltransferase locus detected in a German family. Adv Exp Med Biol 309B:83-6, 1991

Sahota A, Chen J, Behzadian MA, Ravindra R, Takeuchi H, Stambrook PJ, Tischfield JA. 2,8-Dihydroxyadenine lithiasis in a Japanese patient Heterozygous at the adenine phosphoribosyltransferase locus. Am J Hum Genet 48:983-999, 1991

Chen J, Sahota A, Stambrook PJ, Tischfield JA. Polymearse chain reaction amplification and sequence analysis of human mutant adenine phosphoribosyltransferase genes: the nature and frequency of errors caused by Taq DNA polymerase. Mutat Res 249:169-176, 1991

Chen J, Sahota A, Laxdal T, Scrine M, Bowman S, Cui C, Stambrook PJ, Tischfield JA. Identification of a single missenge mutation in the adenine phosphoribosyltransferase (APRT) gene from five Icelandic patients and a British patient, Am J Hum Genet 49:1306-1311, 1991

Sahota A, Chen J, Stambrook PJ, Tischfield JA. Mutational basis of adenine phosphoribosyltransferase deficiency Adv Exp Med Biol. 309B:73-76, 1992.

Fye KH, Sahota A, Hancock DC, Gelb AB, Chen J, Sibley RK, Tischfield JA. Adenine phosphoribosyltransferase deficiency with renal deposition of 2,8-Dihydroxyadenine leading to nephrolithiasis and chronic renal failure. Arch Intern Med 153:7676-770, 1993

Sahota A, Chen J, Stambrook PJ and Tischfield JA. Genetic basis of adenine phosphoribosyltransferase deficiency In: Molecular genetics, biochemistry, and clinical aspects of inherited disorders of purine and pyrimidine metabolism, Ed by Gresser U et al,. Springer-Verlag, Berlin 54-60, 1993

Chen J, Sahota A, Martin GF, Hakoda M, Kamatani N, Stambrook PJ, Tischfield JA. Analysis of germline and in vivo somatic mutations in the human adenine phosphoribosyltransferase gene: Mutation hot spots at the intron 4 splice donor site and at codon 87. Mutat Res 287:217-225, 1993

Sahota A, Chen J, Bye S, Jiang J, Berenyi M, Fekete G, Tischfield JA. Occurrence of a missense mutation in one allele and a seven basepair deletion in the other allele in a patient with adenine phosphoribosyltransferase deficiency. Hum Mutat 3:315-317, 1994.

Bye S, Mallmann R, Simmond HA, Chen J, Tischfield JA, Sahota A. Identification of a 7 basepair deletion in the APRT gene as a cause of 2 8-dihydroxyadenine lithiasis. Clin Investig 72:550-553, 1994

Chen J, Engle SJ, Seilhammer JJ, Tischfield JA. Cloning and expression of a novel low molecular weight Ca2+ dependent human phospholipase A2. J Biol Chem 269:2365-2368, 1994

Bye S, Sahota A, Chen J, Tischfield JA. Analysis of APRT mutations by reverse transcription PCR. Adv Exp Med Biol 370:671-674, 1994

Sahota A, Chen J, Gault MH, Tischfield JA. 2 8-dihydroxyadenine urolithiasis due to a missense mutation in the adenine phosphoribosyltransferase gene Hum Mol Genet 3:817-818, 1994

Chen J, Engle SJ, Seilhamer JJ, Tischfield JA. Cloning, expression and partial characterization of a novel rat phospholipase A2. Biochim Biophys Acta 115-120, 1994

Chen J, Engle SJ, Seilhamer JJ, Tischfield JA. Cloning and characterization of novel rat and mouse low molecular weight Ca2+ -dependent phospholipase A2s containing 16 cysteines J Biol Chem 269:23018-23024, 1994

Tischfield JA, Xia YR, Shih D, Klisak I, Chen J, Engle SJ, Siakotos AN, Winstead M, Seilhamer JJ, Allamand V, Gyapay G, Lusis AJ Low molecular weight, calcium dependent phospholipase A2 genes are linked and map to homologous chromosome regions in mouse and man. Genomics 32:328-333, 1996.

Engle SJ, Stockelman M, Chen J, Boivin G, Yum MN, Ying MY Sahota A, Simmonds AH, Stambrook PJ, Tischfield JA Adenine phosphoribosyl-transferase-deficient mice develop 2 8-dihydroxyadenine nephrolithiasis. Proc Natl Acad Sci USA 93:5307-5312, 1996

Chen J, Shao C, Lazar V, Srivastava CH, Lee WH, Tischfield JA. A localization of group Iic low molecular phospholipase A2mRNA to meiotic cells in the mouse. J Cell Biochem 64:369-375, 1997.

Sheng Z, Knowlton K, Chen J, Hoshijima M, and Brown JH, Chien KR. Cardiotrophin-1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway: Divergence from downstream CT-1 signals for myocardial cell hypertrophy J Biol Chem 272:5783-5791, 1997.

Zou Y, Evans S, Chen J, Kuo H-C, Harvey RP, Chien KR. CARP, a cardiac ankyrin repeat protein, is downstream in the NKX2-5 homeobox gene pathway Development 124:793-804, 1997.

[1998]

Nguyen-Tran VTB, Chen J, Ruiz-Lozano P, and Chien KR. The MLC-2v paradigm for ventricular heart chamber specification, maturation, and morphogenesis. In: Heart Development, Ed by N Rosenthal and R P Harvey, Academic Press, Chapter 5(15), pp255-272, 1998

Chen J, Kubalak SW, Susumu M, Becker KD, Hickey R, Ross J Jr , Chien KR. Unique requirement of myosin light chains-2v in heart function and morphogenesis. J Biol Chem 273:1252-1256, 1998

Chen J, Kubalak SW, Chien KR. Ventricular muscle-restricted targeting of the RXRalpha gene reveals a non-cell-autonomous requirement in cardiac chamber morphogenesis. Development 125:1943-1949, 1998.

Liu X, Hwang H, Cao L, Buckland MI, Cunningham A, Chen J, Chien KR Graham MR, Zhou M. Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cysmoplasmic tail. Proc Natl Acad Sci USA 95:13024-13025, 1998

[1999]

Chen J, and Chien KR. Complexity in Simplicity: Monogenic Disorders and Complex Cardiomyopathies J Clin Invest 103: 1483-1485 1999

Minamisawa S, Gu Y, Ross J Jr , Chien KR, Chen J. A post-transcriptional compensatory pathway in heterozygous ventricular myosin light chain 2-deficient mice results in lack of gene dosage effect during normal cardiacgrowth or hypertrophy J Biol Chem 274:10066-10070, 1999

Hirota H, Chen J, Betz UAK, Rajewsky K, Gu Y, Ross JJR , Muller W, Chien KR. Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell. 97:189-198, 1999

Kuo HK, Chen J, Ruiz-Lozano P, Zou Y, Nemer M, and Chien KR. Control of segmental expression of the cardiac-restricted ankyrin repeat protein gene by distinct regulatory pathways in murine cardiogenesis. Development 126: 4223-4234 1999

Zhou Q, Ruiz-Lozano P, Martone ME, Chen J. Cypher, a striated muscle Restricted PDZ and LIM domain containing protein, binds to alpha-actin-2 and protein kinase C. J Biol Chem 247(28):19807-19813, 1999

[2000]

Wan Y-J, An D, Cai Y, Repa JJ, Chen TH -P, Flores M, Postic K, Magnuson MA, Chen J, Chien KR, French S, Mangelsdorf DJ, Sucov HM. Hepatocyte-specific mutation establishes RXRalpha as a heterodimeric integrator of multiple physiological processes in the liver. Mol Cell Biol 20:4436-4444, 2000

Chu PH, Ruiz-Lozano P, Zhou Q, Cai C, Chen J. Expression Patterns of FHL/SLIM Family Members Suggest Important Functional Roles in Skeletal Muscle and Cardiovascular System. Mech Dev. 95:259-265, 2000

Chu PH, Bardwell W, Gu Y, Ross J Jr , Chen J. FHL2 (SLIM3) is not essential for cardiac development and function. Mol Cell Biol. 20:7460-7462, 2000.

[2001]

Gutstein DE, Morley GE, Tamaddon H, Vaidya D, Schneider MD, Chen J, Chien KR, Stuhlman H, Fishman GI. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of Connexin34. Circ Res 88:333-339, 2001.

Zhou Q, Chu PH, Huang C, Cheng CF, Martone ME, Knoll G, Shelton GD,Evans S, and Chen J. Ablation of Cypher, a PDZ -LIM domain Z-line protein, causes a severe form of congenital myopathy J Cell Biol 155: 605-612 2001

Wettschureck N, Ruetten H , Zywietz A, Gehring D, Wilkie T, Chen J, Chien KR, and Offermanns S. Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Galphaq/Galpha11 in cardiomyocytes. Nat Med 7: 1236-40 2001

[2002]

Ikeda Y, Gu Y, Oh SS, Hoshijima M, Giordano FJ, Chen J, Nigro V, Peterson KL, Chien, KR, and Ross J Jr. Restoration of deficient membrane proteins in the cardiomyopathic hamster by in vivo cardiac gene transfer Circulation 105 :502-8 2002

Shai S-Y, Harpf AE, Babbitt CJ, Fishbein MC, Jordan MC, Chen J, Jiang M, Omura M, Mottino G A , Frank JS , Leil TA, Smith DJ, Cherry SR, Becker RD, Loftus JC, and Ross RS. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure Circ Res. 90: 458-64 2002

Crone SA, Zhou Y-Y, Fan L, Gu Y, Minamisawa S, Peterson KL, Chen J, Kahn R, Gianluigi C, Ross J, Chien KR, and Lee K-F. ErbB2 is Required for the Prevention of Dilated Cardiomyopathy. Nat Med. 8: 459-65 2002.

[2003]

Huang C, Zhou Q, Liang P, Hollander M, Sheikh F, Li X, Greaser M, Shelton GD, Evans S, and Chen J. Characterization and in vivo functional analysis of splice variants of Cypher J Biol Chem 278:7360-7365 2003

Chu PH, Lu JT, Chen J. Gene-engineered models for genetic manipulation and functional analysis of the cardiovascular system in mice Chang Gung Med J 26:868-78 2003.

Minamisawa S , Wang Y, Chen J, Ishikawa Y, Chien KR, and Matsuoka R. Atrial chamber-specific expression of sarcolipin is regulated during development and by hypertrophy J Biol Chem 278: 9570-9575, 2003

Chu X, Chen J, Reedy MC,. Vera K, Sung P K-L , and Sung LA. E-Tmod capping of actin filaments at the slow-growing end is required to establish mouse embryonic circulation Am J Physiol Heart Circ Physiol 284:H1827-38 2003

Huang C, Sheikh F, Hollander M, Cai C, Becker D, Chu P-H, Evans S, and Chen J. Embryonic Atrial Function is Essential For Mouse Embryogenesis, Cardiac Morphogenesis, and Angiogenesis Development. 130:6111-9 2003.

Cai C, Liang X, Shi Y, Chu PH, Pfaff SL, Chen J, and Evans S. A LIM-homeodomain Transcription Factor, Redefines Cardiogenic Fields and Delineates a Cardiac Stem Cell Population. Dev Cell 5:878-889 2003.

Vatta M, Mohapatra B, Jimenez S, Sanchez X, Faulkner G, Perles Z, Sinagra G, Lin JH, Vu TM, Zhou Q, Bowles KR, Di Lenarda A, Schimmenti L, Chrisco MA, Murphy RT, McKenna W, Elliott P, Bowles NE, Chen J, Valle G, and Towbin JA. Mutations in Cypher/ZASP in patients with dilated cardiomyopathy and left ventricular non-compaction J Am Coll Cardiol 42:2014-2027 2003.

Zheng M, Dilly K, Santos Cruz JD, Gu Y, Ursitti JA, Li M, Chen J, Ross Jr J, Chien KR, Lederer JW, Wang Y. Sarcoplasmic Reticulum Calcium Defect in Ras-induced Hypertrophic Cardiomyopathy Heart Am J Physiol Heart Circ Physiol 2003.

[2004]

Barash IA, Mathew L, Chen J, and Lieber RL. Rapid Muscle-Specific Gene Expression Changes After A Single Bout of Eccentric Contractions in the Mouse Am J Physiol Cell Physiol 286:C355-64 2004.

Christensen G, Chen J, Ross J Jr, and Chien KR. Mouse models of human cardiovascular disease. In: Molecular Basis of Cardiovascular Disease 2nd edition, Ed by KR Chien Saunders, Chapter 5, pp72-106, 2004

Ding J-H , Xu X, Chu P-H, Dalton ND, Ross J Jr, Chen J, and Fu X-D. Dilated Cardiomyopathy Caused by Tissue-Specific Ablation of SC35 in the Heart EMBO J 23:885-896 2004

Arimura T, Hayashi T, Terada H, Lee S-Y, Zhou Q, Takahashi M, Ueda K, Nouchi T, Hohda S, Shibutani M, Hirose M, Chen J, Park J-E, Yasunami M, Hayashi H, and Kimura AA. Cypher/ZASP mutation associated with dilated cardiomyopathy alters the binding affinity to protein kinase C J Biol Chem 279:6746-52 2004.

[2005]

Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY; Bermingham Jr JR, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross Jr J, Chen J, Xiao RP, Cheng H, Fu XD. ASF/SF2 Regulated CaMKIIalpha Alternative Splicing Temporally Reprograms Excitation-Contraction Coupling in Cardiac Muscle. Cell 120:59-72 2005

Liang X, Zhou Q, Li X, Sun Y, Lu M, Ross J Jr, and Chen J. PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes. Mol Cell Biol. 25:3056-3062 2005

Wang J, Shaner N, Mittal B, Zhou Q, Chen J, Sanger JM, and Sanger JW. Dynamics of Z-Band Based Proteins in Developing Skeletal Muscle Cells. Cell Motil Cytoskeleton 61:34-48 2005.

Cai C-L, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, Rosenfeld MG, Chen J, and Evans S. Regulation of N-myc transcription by T-box genes dictates regional rates of proliferation during organogenesis Development. 132:2475-87 2005.

Garcia-Rivello H, Taranda J, Said M, Cabeza-Meckert P, Vila-Petroff M, Scaglione J, Ghio S, Chen J, Lai C, Laguens RP, Lloyd KC, and Hertig CM. Dilated cardiomyopathy in Erb-b4-deficient ventricular muscle Am J Physiol Heart Circ Physiol 289:H1153-60 2005.

Li X, Zima AV, Sheikh F, Blatter, LA, and Chen J. Endothelin-1-induced arrhythmogenic Ca2+ signaling is abolished in atrial myocytes of inositol-1,4,5-trisphosphate(IP3)-receptor type 2-deficient mice Circ Res 96:1274‚ 1281. 2005

Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schuele R, Darnay B, Novack DV, Ross FP, and Teitelbaum SL. FHL2 inhibits the activated osteoclast in a TRAF6 dependent manner J Clin Invest 115: 2742-2751 2005

[2006]

Lai CF, Bai S, Uthgenannt BA, Halstead LR, McLoughlin P, Schafer BW, Chu PH, Chen J, Otey CA, Cao X, Cheng, SL. Four and Half Lim Protein 2 (FHL2) Stimulates Osteoblast Differentiation. J Bone Miner Res 21:17-28 2006

Peng X, Kraus MS, Wei H, ShenTL, Pariaut M, Alcaraz A, Ji G, Cheng L, Yang Q, Kotlikoff MI, Chen J, Chien K, Gu H, and Guan JL. Inactivation of focal adhesion kinase in cardiomyocytes promotes cardiac eccentric hypertrophy and fibrosis in mice J Clin Invest 116: 217 - 227 2006

Wu X, Zhang T, Bossuyt J, Li X, McKinsey T, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. Excitation-Transcription Coupling in Adult Cardiac Myocytes: Local InsP3-dependent Perinuclear Ca Signaling Activates HDAC5 Nuclear Export J Clin Invest 116: 675-682 2006

Bang ML, Li X, Littlefield R, Bremner S, Thor A, Knowlton KU, Lieber RL, and Chen J. Nebulin deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 173:905-916 2006

Ricote M, Snyder CS, Leung HY, Chen J, Chien KR, Glass CK J. Leukoc Biol Normal hematopoiesis after conditional targeting of RXR{alpha} in murine hematopoietic stem/progenitor cells J Leukoc Biol 80:850-61 2006

Sheikh F, Chen Y, Liang X, Hirschy A, Stenbit AE, Gu Y, Dalton ND, Yajima T, Lu Y, Knowlton KU, Peterson KL, Perriard JC, and Chen J. alpha E-catenin Inactivation Disrupts the Cardiomyocyte Adherens Junction Resulting in Cardiomyopathy and Susceptibility to Wall Rupture Circulation 114:1046-55 2006

Govoni KE, Baylink DJ, Chen J, Mohan S. Disruption of Four-and-a-Half LIM 2 Decreases Bone Mineral Content and Bone Mineral Density in Femur and Tibia Bones of Female Mice Calcif Tissue Int 79:112-7 2006

[2007]

Kudo LC, Karsten SL, Chen J, Levitt P, Geschwind DH. Genetic analysis of anterior-posterior expression gradients in the developing mammalian forebrain Cereb Cortex 17:2108-22 2007

Xiong D, Yajima T, Stenbit, A, Dublin A, Dalton N, Summers-Torres D, Molkentin JD, Duplain H, Chen J, Knowlton KU. Cardiac Restricted, Inducible Expression of Enteroviral Protease 2A is Sufficient to Induce Dilated Cardiomyopathy. Circulation. 115:94-10 2007

Sun Y, Liang X, Najafi N, Cass M, Lin L, Cai C, Chen J, and Evans S. Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells Dev Biol. 304:286-96 2007

Sheikh F and Chen J. Mouse models for cardiomyopathy research Progress in Pediatric Cardiology 24:24-32, 2007

Sheikh F, Bang ML, Lange, S, and Chen J. Zeroing in on the role of Cypher in striated muscle function, signaling and human disease Trends in Cardiovascular Medicine 17:259-263 2007

Liang X, Sun Y, Schneider J, Ding JH, Cheng H, Ye M, Bhattacharya S, Rearden A, Evans SM, and Chen J. Pinch1 is required for Normal Development of Cranial and Cardiac Neural Crest Derived Structures Circ Res 100:527-35 2007

Barash IA, Bang ML, Mathew L, Greaser ML, Chen J, and Lieber RL. Structural and Regulatory Roles of the Muscle Ankyrin Repeat Protein Family in Skeletal Muscle Am J Physiol Cell Physiol 293:C218-27 2007

Fiacco TA, Agulhon C, Taves SR, Petravicz J, Casper KB, Dong X, Chen J, and McCarthy KD. Selective stimulation of astrocyte Ca2+ in situ using astrocyte-specific expression of Gq-coupled receptor does not affect excitatory synaptic activity, elevate neuronal Ca2+, or produce neuronal slow inward currents Neuron, 54:611-626 2007.

Bao X, Lu CM, Liu F, Gu Y, Dalton N, Zhu BQ, Foster E, Chen J, Karliner JS, Ross J Jr , Simpson PC, Ziegler MG. Epinephrine Is Required for Normal Cardiovascular Responses to Stress in the Phenylethanolamine N-methyltransferase Knockout Mouse Circulation 116:1024-3 2007

Lin L, Cui L, Zhou W, Dufort D, Zhang X, Cai CL, Bu L, Yang L, Kemler R, Rosenfeld M, Chen J, Evans SM. alpha-catenin directly regulates islet1 expression in cardiovascular progenitors, and is required for multiple aspects of cardiogenesis. Proc Natl Acad Sci USA 104:9313-8 2007

Lucitti JL, Jones EAV, Huang C, Chen J, Fraser SE, Dickinson ME. Vascular Remodeling of the Mouse Yolk Sac Requires Hemodynamic Force. Development 134:3317-26 2007

Gustafson-Wagner EA, Sinn HW, Chen YL, Wang DZ, Reiter RS, Lin JL, Yang B, Williamson RA, Chen J, Lin CI, Lin JJ. Loss of mXin{alpha}, an intercalated disc protein, results in cardiac hypertrophy and cardiomyopathy with conduction defects Am J Physiol Heart Circ Physiol 293:H2680-92, 2007.

[2008]

Luo D, Yang D, Lan X, Li K, Li X, Chen J, Zhang Y, Xiao RP, Han Q, and Cheng H. Nuclear Ca2+ sparks and waves mediated by inositol 1,4,5-trisphosphate receptors in neonatal rat cardiomyocytes Cell Calcium 43:165-74 2008.

Zhang J, Bang ML, Gokhin DS, Lu Y, Cui L, Li X, Gu Y, Dalton N, Scimia MC, Peterson K, Lieber RL, and Chen J. Syncoilin is required for generating maximum isometric stress in skeletal muscle but dispensable for muscle cytoarchitecture Am J Physiol Cell Physiol 294:C1175-82 2008. PMC2749034

Labalette C, Nouët Y, Sobczak-Thepot J, Armengol C, Levillayer F, Gendron MC, Renard CA, Regnault B, Chen J, Buendia MA, Wei Y. The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation J Biol Chem 283:15201-8 2008

Peng X, Wu X, Druso JE, Wei H, Park AY, Kraus MS, Alcaraz A, Chen J, Chien S, Cerione RA, Guan JL. Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice Proc Natl Acad Sci U S A 105(18):6638-43 2008.

Cai CL, Martin JC, Sun Y, Cui L, Wang L, Ouyang K, Yang L, Bu L, Liang X, Zhang X, Stallcup WB, Denton CP, McCulloch A, Chen J, and Evans SM. A myocardial lineage derives from Tbx18 epicardial cells Nature, 454:104-8 2008.

Lim BK, Xiong D, Dorner A, Youn TJ, Yung A, Liu T, Gu Y, Dalton ND, Wright AT, Evans SM, Chen J, Peterson KL, McCulloch AD, Yajima T, and Knowlton KU. Coxsackievirus and Adenovirus Receptor (CAR) in the Heart is Essential for Atrioventricular-node Function and Localization of Connexin 45 J Clin Invest 118:2758-70 2008.

Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JPY, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. Superoxide Flashes in Single Mitochondria Cell, 134:279-90 2008.

Park HS, Betzenhauser MJ, Won JH, Chen J, Yule DJ. The type-2 insp3 receptor determines the sensitivity of insp3-induced ca2+ Release to atp in pancreatic acinar cells J Biol Chem 283:26081-8 2008.

Ross RS and Chen J. Models that Buzz, Squeak, Ribbit and Oink: Using a Variety of Species to Study Cardiovascular Disease Drug Discov Today Dis Models 5:113-115 2008.

Vasilevski O, Grubb DR, Filtz TM, Yang S, McLeod-Dryden TJ, Luo J, Karna D, Chen J, Woodcock EA. Ins(1,4,5)P(3) regulates phospholipase Cbeta1 expression in cardiomyocytes J Mol Cell Cardiol 45:679-84 2008.

Chu PH, Yeh LK, Lin HC, Jung SM, Ma D HK, Wang IJ , Wu HH, Shiu TF, and Chen J. Deletion of the FHL2 Gene Attenuates Neovascularization after Corneal Injury. Invest Ophthalmol Vis Sci 49(12):5314-8 2008

Chen Q, Chen H, Zheng D, Kuang C, Fang H, Zou B, Zhu W, Bu G, Jin T, Wang Z, Zhang X, Chen J, Field LJ, Rubart M, Shou W, Chen Y. Smad7 is required for the development and function of heart J Biol Chem 284:292-300 2009

Sheikh F, Raskin A, Chu PH, Lange S, Domenighetti AA, Zheng M, Liang X, Zhang T, Yajima Y, Gu Y, Dalton ND, Mahata SK, Dorn II GW,, Brown JH, Peterson KL, Omens JH, McCulloch AD, and Chen J. An FHL1-containing Complex within the Cardiomyocyte Sarcomere Mediates Hypertrophic Biomechanical Stress Responses in Mice. J Clin Invest 118:3870-80 2008 PMC2575833

[2009]

Princen F, Bard E, Sheikh F, Zhang SS, Wang J, Zago WM, Wu D, Diaz Trelles R, Bailly-Maitre B, Kahn CR, Chen Y, Reed JC, Tong GG, Mercola M, Chen J, Feng GS. Deletion of Shp2 Tyrosine Phosphatase in Muscle Leads to Dilated Cardiomyopathy, Insulin Resistance and Premature Death Mol Cell Biol 29:378-88 2009

Zheng M, Cheng H, Li X, Zhang J, Cui L, Ouyang K, Han L, Zhao T, Gu Y, Dalton ND, Bang ML, Peterson KL, and Chen J. Cardiac-Specific Ablation of Cypher Leads to a Severe Form of Dilated Cardiomyopathy with Premature Death. Hum Mol Genet 18:701-13 2009 PMC2722217

Gokhin DS, Bang ML, Zhang J, Chen J, Lieber RL. Reduced thin filament length in nebulin-knockout skeletal muscle alters isometric contractile properties. Am J Physiol Cell Physiol. 296:C1123-32, 2009.

Liang X, Sun Y, and Chen J. The Role of PINCH in Cardiac Development and Remodeling. Journal of Investigative Medicine 57:842-8, 2009

Sheikh F, Ross RS, and Chen J. The Cell-Cell Connection to Cardiac Disease. Trends in Cardiovascular Medicine 19:182-190, 2009

Andersson KB, Birkeland JA, Finsen AV, Louch WE, Sjaastad I, Wang Y, Chen J, Molkentin JD, Chien KR, Sejersted OM, Christensen G. Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol 47:180-7, 2009.

Ling H, Zhang T, Pereira L, Means CK, Cheng H, Gu Y, Dalton ND, Peterson KL, Chen J, Bers D, Brown JH. Requirement for CaMKIIalpha in the transition from pressure overload-induced cardiac hypertrophy to heart failure. J Clin Invest 119:1230-40 2009

Lipp L, Wurm A,. Pannicke T, Wiedemann P, Reichenbach A, Chen J, and Bringmann A. Calcium responses mediated by type 2 IP3-receptors are required for osmotic volume regulation of retinal glial cells in mice. Neuroscience Letters 457:85-8 2009

Lange S, Ouyang K, Meyer G, Cui L, Cheng H, Lieber RL and Chen J. Obscurin determines longitudinal SR architecture. J Cell Sci 122:2640-50 2009

Liang X, Sun Y, Ye M, Scimia MC, Cheng H, Martin J, Rearden A, Wu C, Peterson, KL, Powell HC, Evans SM, and Chen J. Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality. Circulation 120:568-76 2009 PMC2738591

Bang ML, Caremani M, Brunello E, Littlefield R, Lieber RL, Chen J, Lombardi V, Linari M. Nebulin plays a direct role in promoting strong actin-myosin interactions. FASEB J 23:4117-25 2009 PMC2812046

Andersson KB, Finsen AV, Sjåland C, Winer LH, Sjaastad I, Odegaard A, Louch WE, Wang Y, Chen J, Chien KR, Sejersted OM, Christensen G. Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models Cell Calcium 46:219-225, 2009.

Elia L, Quintavalle M, Zhang J, Contu R, Cossu L, Latronico MVG, Peterson KL, Indolfi C, Catalucci D, Chen J, Courtneidge SA, and Condorelli G. Regulation of vascular homeostasis, and smooth muscle cell migration and podosome formation, by miR-143 and -145. Cell Death & Differentiation 16:1590-8, 2009.

Hu X, Xu X, Zhu G, Atzler D, Kimoto M; Chen J, Schwedhelm E, Lueneburg N, Boeger RH, Zhang P, and Chen Y. Vascular endothelial specific DDAH1 gene deficient mice reveal vascular endothelium as the primary site to remove toxic methylarginines. Circulation 120:2222-9, 2009

[2010]

Zhang J, Felder A, Liu Y, Guo LT, Lange S, Dalton ND, Gu Y, Peterson KL, Mizisin AP, Shelton GD, Lieber RL, and Chen J. Nesprin 1 is critical for nuclear positioning and anchorage. Hum Mol Genet 19:329-41, 2010 PMC2796894

Wurm A, Lipp S, Pannicke T, Linnertz R, Kruegel U, Schulz A, Faerber K, Zahn D, Grosse J, Wiedemann P, Chen J, Schoeneberg T, Illes P, Reichenbach A, Bringmann A. Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. J Neurochem 112:1261-72, 2010

Labalette C, Nouët Y, Levillayer F, Colnot S, Chen J, Claude V, Huerre M, Perret C, Buendia MA, Wei Y. Deficiency of the LIM-only protein FHL2 reduces intestinal tumorigenesis in Apc mutant mice. PLoS ONE 5:e10371, 2010 PMC2860980

Zheng M, Cheng H, Banerjee I, and Chen J. ALP/Enigma PDZ-LIM Domain Proteins in the Heart. Journal of Molecular Cell Biology 2:96-102, 2010.

Cruz LN, Guerra M, Kruglov E, Mennone A, Garcia CRS, Chen J, and Nathanson MH. Regulation of Multidrug Resistance-Associated Protein 2 by Calcium Signaling in Rats. Hepatology 52:327-37, 2010.

Zhang DH, Latronico MVG, Zhang J, Contu1 R, Rizzi R, Catalucci D, Peterson1 KL, Brown JH, Chen J, Sonenberg N, Condorelli G. mTORC-1 regulates cardiac function and myocyte survival through 4E-BP-1 inhibition. J Clin Invest 120:2805-16, 2010 PMC2912201

Cheng H, Kimura K, Peter AK, Cui L, Ouyang K, Shen T, Liu Y, Gu Y, Dalton ND, Evans SM, Knowlton KU, Peterson KL, and Chen J. Loss of Enigma Homolog Protein Results in Dilated Cardiomyopathy. Circ Res 107:348-5 2010

Zhao G, Neeb ZP, Leo MD, Pachuau J, Adebiyi A, Ouyang K, Chen J, Jaggar JH. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol 136:283-91 2010

[2011]

Efe JA, Hilcove S, Kim J, Zhou H, Ouyang K, Wang G, Chen J, and Ding S. Conversion of Mouse Fibroblasts into Cardiomyocytes using a Direct Reprogramming Strategy. Nature Cell Biol 13:215-22 2011

Peter AK, Cheng H, Ross RS, Knowlton KU, and Chen J. The Costamere Bridges Sarcomeres To The Sarcolemma In Striated Muscle. Progress in Pediatric Cardiology 31:83-88, 2011

Cheng H, Zheng M, Peter AK, Kimura K, Li X, Ouyang K, Shen T, Cui Li, Frank D, Dalton ND, Gu Y, Frey N, Peterson KL, Evans SM, Knowlton KU, Sheikh F, and Chen J. Selective Deletion of Long but not Short Cypher Isoforms Leads to Late Onset Dilated Cardiomyopathy. Hum Mol Genet. 20:1751-62 2011

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, and Chen SRW. Unique Action of Carvedilol and Its Novel Analogues: Suppression of Arrhythmogenic Store-Overload-Induced Ca2+ Release (SOICR). Nature Medicine 17:1003-9, 2011

Fang H, Chen M, Ding Y, Shang W, Xu J, Zhang X, Zhang W, Li K, Xiao Y, Gao F, Shang S, Li JC, Tian XL, Wang SQ, Zhou J, Weisleder N, Ma J, Ouyang K, Chen J, Wang X, Zheng M, Wang W, Zhang X, Cheng H. Imaging superoxide flash and metabolism-coupled mitochondrial permeability transition in living animals. Cell Res 21:1295-304, 2011

Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM. Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. J Clin Invest. 1;121(12):4640-54. 2011

[2012]

Banerjee I, Zhang J, Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, and Chen J. Thymosin Beta 4 is Dispensable for Murine Cardiac Development and Function. Circ Res. 110:456-64. 2012. PMID:22158707

Wang Q, Domenighetti A, Schäfer S, Weber J, Simon A, Maillard M, Pedrazzini T, Chen J, Lehr H-A, and Burnier M. Impact of salt on cardiac differential gene expression and coronary lesion in normotensive mineralocorticoid treated mice. Am J Physiol Regul Integr Comp Physiol. 302: R1025-33. 2012

Sheikh F, Ouyang K, Campbell SG, Lyon RC, Chuang J, Fitzsimons D, Tangney J, Hidalgo CG, Chung CS, Cheng H, Dalton ND, Gu Y, Kasahara H, Ghassemian M, Omens JH, Peterson KL, Granzier HL, Moss RL, McCulloch AD, Chen J. Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest. 122:1209-21. 2012 PMC3314469.

Wang Y, Li G, Goode J, Paz JC, Ouyang K, Screaton R, Fischer WH, Chen J, Tabas I, and Montminy M. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature. 485:128-32. 2012

Xiao G, Cheng H, Cao H, Chen K, Tu Y, Yu S, Jiao H, Yang S, Im HJ, Chen D, Chen J*, and Wu C. Critical role of Filamin-binding LIM protein 1 (FBLP-1)/Migfilin in regulation of bone remodeling. J Biol Chem. 2012 May 3. [Epub ahead of print]. * Co-corresponding author.

Lange L, Perera S, The P, and Chen J. Obscurin and KCTD6 regulate cullin-dependent small ankyrin-1 (sAnk1.5) protein turnover. Mol Biol Cell. 2012 May 9. [Epub ahead of print].

Zhao T, Huang X, Han L, Wang X, Cheng H, Zhao Y, Chen Q, Chen J, Cheng H, Xiao R, and Zheng M. Central Role of Mitofusin 2 in Autophagosome-Lysosome Fusion in Cardiomyocytes J. Biol. Chem. published May 22, 2012 as doi:10.1074/jbc.M112.379164.

Section 'Sub' Navigation:

Ju Chen, PhD

Page 'Breadcrumb' Navigation:

Ju Chen Laboratory In the Department of Medicine