Ju Chen Laboratory In the Department of Medicine

"Understanding the Molecular Basis of Cardiac and Skeletal Muscle Disease"

Prof. Dr. Ju Chen

  • Ju Chen, PhD.
    Professor of Medicine
    AHA Endowed Chair
    Director of Basic Cardiac Research
    School of Medicine
    UC San Diego
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About the Lab

My lab is interested in understanding the molecular basis of cardiac and skeletal myopathy. We are also studying a number of signaling pathways underlying cardiac hypertrophy and heart failure.
More about our research >

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Spotlight on:

  • April 2021: mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif. More information here.
  • April 2021: Molecular Characterisation of Titin N2A and Its Binding of CARP Reveals a Titin/Actin Cross-linking Mechanism. More information here.
  • October 2020: p38 MAPK reins in right ventricular growth. More information here.
  • August 2020: Homozygous G650del nexilin variant causes cardiomyopathy in mice. More information here.
  • July 2020: Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes. More information here.
  • Older news here.

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