Ju Chen Laboratory In the Department of Medicine

News History

  • December 2018: A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure. More information here.
  • October 2018: IP3R1 plays a critical role in regulating physiological function of the GI tract – a new manuscript in the Journal of Gastroenterology. More information here.
  • October 2018: Ushering in the cardiac role of Ubiquilin1 – a new commentary in 'JCI'. More information here.
  • August 2018: Generation and analysis of striated muscle selective LINC complex protein mutant mice – a new manuscript in Methods Molecular Biology. More information here.
  • August 2018: Cell surface marker signatures are a broadly applicable strategy for the enrichment of ventricular cardiomyocytes derived from human embryonic stem cells - a new manuscript in Stem Cell Reports. More information here.
  • August 2018: TBX20 plays a key role in atrial development - a new manuscript in Circulation Research. More information here.
  • May 2018: The deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders – a new manuscript in Nature Communications. More information here.
  • April 2018: aPKCζ-dependent repression of Yap is necessary for functional restoration of irradiated salivary glands with IGF – a new manuscript in Scientific Reports. More information here.
  • March 2018: Luma is not essential for murine cardiac development and function – a new manuscript in Cardiovascular Research. More information here.
  • February 2018: Infarct fibroblasts do not derive from bone marrow lineages – a new manuscript in Circle Research. More information here.
  • October 2017: Luma is not essential for murine cardiac development and function - a new manuscript in Cardiovascular Research. More information here.
  • September 2017: HSPB7 is indispensable for heart development by modulating actin filament assembly - a new manuscript at "PNAS". More information here.
  • July 2017: Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy - a new highlight manuscript and commentary at 'JCI'. More information here.
  • May 2017: Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle - a new manuscript on a cover page of 'JCB'. More information here.
  • May 2017: Contributing to an article on Danon disease. More information here.
  • May 2017: Contributing to an article on FHL2 function. More information here.
  • March 2017: Contributing to an article on pericyte biology. More information here.
  • February 2017: A new method to create single-amino-acid-substituted and floxed mice is published in 'Science Reports'. More information here.
  • February 2017: Contributing to an article on role of NUMB and NUMBL in cardiomyocyte cell cycle regulation. More information here.
  • November 2017: Contributing to an article on Epac1 function. More information here.
  • October 2016: IP3 receptors regulate vascular smooth muscle contractility and hypertension - a new manuscript at 'JCI Insight'. More information here.
  • October 2016: Investigating the role of PPARgamma for cardiac hypertrophy in a new manuscript at 'JCI Insight'. This work has been featured on journal cover page. More information here.
  • August 2016: Julius Bogomolovas receives an Marie Curie Individual fellowship.
  • August 2016: Publishing an article on Kindlin-2 functions here.
  • June 2016: Contributing to an article on Ankrd1 functions. More information here.
  • June 2016: Contributing to an article on Tbx20 functions. More information here.
  • November 2015: Presenting "Calcium LINCS to heart disease" at the 2015 AHA Scientific Sessions.
  • October 2015: Contributing to an article on cardiomyocyte cell cycle regulation. More information here.
  • August 2015: Contributing to an article on Isl1 function. More information here.
  • June 2015: Contributing to an article on HIF1alpha function in fetal cardiomyocytes. More information here.
  • May 2015: New article on Cypher & ENH protein function for cardiac development.
    More information here.
  • May 2015: Contributing to an article on Nebulette protein function for cardiac function. More information here.
  • March 2015: Contributing to an article on oxidative stress and cardiomyocyte apoptosis. More information here.
  • March 2015: Contributing to an article on EPAC distribution and function. More information here.
  • March 2015: Contributing to an article on splicing factor functions in pressure overload cardiomyopathy model. More information here.
  • March 2015: Contributing to an article on PKC-delta activation. More information here.
  • March 2015: Contributing to an article on miR-143/145 functions in endothelial cells. More information here.
  • February 2015: New article with insights into Naxos disease and the role of Plakoglobin by Dr. Matthew Stroud. Get more information on the project here.
  • October 2014: Contributing to a new manuscript EPAC1 function. Go to the article.
  • September 2014: New manuscript on IP3 Receptor function. Read it here.
  • September 2014: Contributing to a new manuscript on Muscle Ankyrin Repeat Protein functions. Read it here.

Learn more about our research focus

We are interested in elucidating molecular mechanisms behind human muscle diseases using genetically engineered mouse models.

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